The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Sep. 28, 2017
Applicant:
University of Southern California, Los Angeles, CA (US);
Inventors:
Robert D. Ladner, Belfast, GB;
Bruno Giethlen, Altorf, FR;
Assignee:
University of Southern California, Los Angeles, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/06 (2006.01); C07D 403/06 (2006.01); A61K 31/496 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); C12Q 1/6876 (2018.01);
U.S. Cl.
CPC ...
C07D 413/06 (2013.01); A61K 31/496 (2013.01); A61K 31/513 (2013.01); A61K 31/5377 (2013.01); C07D 403/06 (2013.01); C12Q 1/6876 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. Thioanalogs of the uracil isostere where a thione replaces each of the ketone are also disclosed.