The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Apr. 26, 2012
Applicants:
Che-hong Chen, Fremont, CA (US);
Daria Mochly-rosen, Menlo Park, CA (US);
Quynh-thu Le, Stanford, CA (US);
Inventors:
Che-Hong Chen, Fremont, CA (US);
Daria Mochly-Rosen, Menlo Park, CA (US);
Quynh-Thu Le, Stanford, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); C07D 317/58 (2006.01); A61K 31/36 (2006.01); C07C 233/29 (2006.01); C07C 233/11 (2006.01); C07D 215/24 (2006.01); C07D 235/16 (2006.01); C07D 317/50 (2006.01);
U.S. Cl.
CPC ...
C07D 317/58 (2013.01); A61K 31/36 (2013.01); C07C 233/11 (2013.01); C07C 233/29 (2013.01); C07D 215/24 (2013.01); C07D 235/16 (2013.01); C07D 317/50 (2013.01);
Abstract
The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an individual undergoing radiotherapy for head and neck cancer.