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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10457642 B1

PDFFull Text
Date of Patent:
Oct. 29, 2019

Filed:

Apr. 26, 2016

-astatine containing radiotherapeutics for the treatment of cancer

Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

Daniel A. Pryma, Bryn Mawr, PA (US);

Brian P. Lieberman, Philadelphia, PA (US);

Mehran Makvandi, Philadelphia, PA (US);

Robert H. Mach, Wallingford, PA (US);

Assignee:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Attorney:

BakerHostetler

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Jagadishwar R Samala

Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 9/00 (2006.01); A61K 41/00 (2006.01); C07D 217/04 (2006.01); G21H 5/02 (2006.01); A61K 51/04 (2006.01); C07D 209/44 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
C07D 217/04 (2013.01); A61K 9/0019 (2013.01); A61K 41/0038 (2013.01); A61K 45/06 (2013.01); A61K 51/0446 (2013.01); A61K 51/0455 (2013.01); A61N 5/10 (2013.01); A61P 35/00 (2018.01); C07D 209/44 (2013.01); G21H 5/02 (2013.01);
Abstract

Described herein is an alpha-emitting radionuclide,At, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described herein, a compound of formula (I), wherein R-R, m, and n are defined herein, was prepared and utilized in in vitro and in vivo tumor targeting of alpha-emitting sigma-2 ligand in a breast cancer model. In one embodiment, the compound is 5-(At)—N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide.

Find Patent Forward Citations

Pryma, Daniel. (2019). -astatine containing radiotherapeutics for the treatment of cancer (U.S. Patent No. 10457642). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10457642

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