The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Jun. 15, 2015
Applicant:
Ngm Biopharmaceuticals, Inc., South San Francisco, CA (US);
Assignee:
NGM Biopharmaceuticals, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 38/13 (2006.01); A61K 38/20 (2006.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); C07K 14/50 (2006.01); A61K 45/06 (2006.01); A61K 31/155 (2006.01); A61K 31/165 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/573 (2006.01); A61K 31/575 (2006.01); A61K 31/64 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1825 (2013.01); A61K 31/155 (2013.01); A61K 31/165 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/573 (2013.01); A61K 31/575 (2013.01); A61K 31/64 (2013.01); A61K 38/13 (2013.01); A61K 38/208 (2013.01); A61K 38/26 (2013.01); A61K 38/28 (2013.01); A61K 45/06 (2013.01); C07K 14/50 (2013.01); C07K 2319/00 (2013.01);
Abstract
Provided herein are methods of modulating bile acid homeostasis or treating a bile-acid related or associated disorder, comprising using variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), in combination with agents effective in modulating bile acid homeostasis or treating a bile-acid related or associated disorder.