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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10456449 B1

PDFFull Text
Date of Patent:
Oct. 29, 2019

Filed:

Jun. 15, 2015

Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases

Applicant:

Ngm Biopharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Lei Ling, Foster City, CA (US);

Hui Tian, Foster City, CA (US);

Assignee:

NGM Biopharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:

Jones Day

Primary Examiner:

Christine J Saoud

Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 38/13 (2006.01); A61K 38/20 (2006.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); C07K 14/50 (2006.01); A61K 45/06 (2006.01); A61K 31/155 (2006.01); A61K 31/165 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/573 (2006.01); A61K 31/575 (2006.01); A61K 31/64 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1825 (2013.01); A61K 31/155 (2013.01); A61K 31/165 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/573 (2013.01); A61K 31/575 (2013.01); A61K 31/64 (2013.01); A61K 38/13 (2013.01); A61K 38/208 (2013.01); A61K 38/26 (2013.01); A61K 38/28 (2013.01); A61K 45/06 (2013.01); C07K 14/50 (2013.01); C07K 2319/00 (2013.01);
Abstract

Provided herein are methods of modulating bile acid homeostasis or treating a bile-acid related or associated disorder, comprising using variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), in combination with agents effective in modulating bile acid homeostasis or treating a bile-acid related or associated disorder.

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Ling, Lei. (2019). Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases (U.S. Patent No. 10456449). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10456449

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