The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2019
Filed:
Feb. 28, 2017
Applicant:
Medivir Aktiebolag, Huddinge, SE;
Inventors:
Mark Albertella, Huddinge, SE;
Anders Eneroth, Huddinge, SE;
Björn Klasson, Huddinge, SE;
Fredrik Öberg, Huddinge, SE;
John Öhd, Huddinge, SE;
Assignee:
Medivir Aktiebolag, Huddinge, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/513 (2006.01); A61K 31/675 (2006.01); A61K 31/685 (2006.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/685 (2013.01); A61K 9/0053 (2013.01); A61K 31/44 (2013.01); A61K 31/513 (2013.01); A61K 31/675 (2013.01); A61P 35/00 (2018.01);
Abstract
Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine with the formula: where Y is C-Cstraight or branched chain alkyl, X is H, halo, C-Ccycloalkyl or C-Calkyl and Z is H or fluoro, or a pharmaceutically acceptable salt thereof, shows surprising utility in the treatment of liver cancer or liver metastasis.