The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 29, 2019

Filed:

Sep. 06, 2016
Applicants:

Zhejiang Huahai Pharmaceutical Co., Ltd, Linhai, CN;

Shanghai Synergy Pharmaceutical Sciences Co., Ltd, Shanghai, CN;

Inventors:

Jian Ge, Shanghai, CN;

Yunfei Li, Shanghai, CN;

Zhen Zhang, Shanghai, CN;

Yijin Wang, Shanghai, CN;

Jiamiao Wang, Shanghai, CN;

Tao Cheng, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); C07D 239/88 (2006.01); A61K 31/5355 (2006.01); C07D 217/24 (2006.01); C07D 239/91 (2006.01); A61P 9/10 (2006.01); A61P 25/28 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61K 31/4418 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5355 (2013.01); A61K 31/4418 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61P 3/06 (2018.01); A61P 3/10 (2018.01); A61P 9/10 (2018.01); A61P 25/28 (2018.01); C07D 217/24 (2013.01); C07D 239/91 (2013.01);
Abstract

Provided are a compound of the formula below, and a pharmaceutically acceptable salt or stereoisomer thereof that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds, a pharmaceutically acceptable salt or stereoisomer thereof and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds, a pharmaceutically acceptable salt or stereoisomer thereof and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases.


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