The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2019

Filed:

Apr. 15, 2019
Applicants:

Genentech, Inc., South San Francisco, CA (US);

F. Hoffmann-la Roche Ag, Basel, CH;

Biogen Inc., Cambridge, MA (US);

Inventors:

Mark Totoritis, Rancho Santa Fe, CA (US);

Timothy Mark Shaw, Hertfordshire, GB;

Sunil Agarwal, Corte Madera, CA (US);

David Yocum, San Mateo, CA (US);

Ariella Kelman, Hillsborough, CA (US);

Assignees:

Genetech, Inc., South San Francisco, CA (US);

F. Hoffmann-La Roche AG, Basel, CH;

Biogen Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 31/519 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 47/68 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2887 (2013.01); A61K 31/519 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/6849 (2017.08); C07K 16/2896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01);
Abstract

Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject in an amount effective to slow progression of the joint damage as measured by radiography. Further provided are articles of manufacture useful for such methods.


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