The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2019

Filed:

Jun. 09, 2017
Applicant:

General Electric Company, Schenectady, NY (US);

Inventors:

Erik Leeming Kvam, Albany, NY (US);

Bruce Allan Hay, Niskayuna, NY (US);

Ernest William Kovacs, San Diego, CA (US);

Assignee:

General Electric Company, Schenectady, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/36 (2006.01); C08L 71/02 (2006.01); C07K 16/00 (2006.01); B01D 11/04 (2006.01); C12N 15/11 (2006.01); B01D 17/02 (2006.01); C07K 1/14 (2006.01); B01J 20/26 (2006.01); B01D 15/38 (2006.01); C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
C07K 1/36 (2013.01); B01D 11/0492 (2013.01); B01D 15/3804 (2013.01); B01D 17/0217 (2013.01); B01J 20/264 (2013.01); C07K 1/145 (2013.01); C07K 16/00 (2013.01); C08L 71/02 (2013.01); B01D 11/0488 (2013.01); C12N 15/115 (2013.01); C12N 2310/16 (2013.01); C12N 2310/351 (2013.01);
Abstract

A method for purification of a target in a solution includes providing a target in a solution, the solution comprising one or more contaminants, providing a polymer conjugate in the solution, wherein the polymer conjugate is configured to specifically bind the target, incubating the solution at a first temperature to facilitate binding of the polymer conjugate to the target, providing an environmentally-responsive block copolymer in the solution, wherein the environmentally-responsive block copolymer comprises one or more of an ethylene oxide (EO), a propylene oxide (PO), or an EO/PO block copolymer, and heating the solution comprising the environmentally-responsive block copolymer and the polymer conjugate bound to the target at a second temperature to initiate a liquid-liquid phase separation, wherein the liquid-liquid phase separation produces an aqueous phase and a liquid polymer phase, and wherein the liquid polymer phase comprises the polymer conjugate bound to the target.


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