The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2019

Filed:

Jun. 29, 2018
Applicant:

Vasthera Co. Ltd., Seoul, KR;

Inventors:

Sang Won Kang, Seoul, KR;

Dong Hoon Kang, Gyeonggi-do, KR;

Doo Jae Lee, Seoul, KR;

Assignee:

Vasthera Co. Ltd., Seoul, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/08 (2006.01); C12Q 1/26 (2006.01); A61K 31/00 (2006.01); A61K 31/548 (2006.01);
U.S. Cl.
CPC ...
C07D 513/08 (2013.01); A61K 31/00 (2013.01); A61K 31/548 (2013.01); C12Q 1/26 (2013.01); G01N 2333/90212 (2013.01); G01N 2500/02 (2013.01);
Abstract

The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.


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