The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2019

Filed:

Jul. 01, 2016
Applicants:

Eli Lilly and Company, Indianapolis, IN (US);

Audion Therapeutics, Amsterdam, NL;

Inventors:

Julia Marie Clay, Indianapolis, IN (US);

Albert Edge, Brookline, MA (US);

Philip Arthur Hipskind, New Palestine, IN (US);

John C. Gill, Boston, MA (US);

Bharvin Kumar Patel, Carmel, IN (US);

Helmuth Hendrikus Gerardus Van Es, Virac, FR;

Aaron D. Wrobleski, Indianapolis, IN (US);

Gaiying Zhao, Carmel, IN (US);

Assignees:

Eli Lilly and Company, Indianapolis, IN (US);

Audion Therapeutics, Amsterdam, NL;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 487/14 (2006.01); C07D 471/14 (2006.01); A61P 35/02 (2006.01); A61P 27/16 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61P 27/16 (2018.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07D 471/14 (2013.01); C07D 487/14 (2013.01); C07B 2200/07 (2013.01);
Abstract

The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell loss, and inducing auditory hair cell generation.


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