The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2019

Filed:

Apr. 28, 2016
Applicants:

Chongqing Fochon Pharmaceutical Co., Ltd., Chongqing, CN;

Shanghai Fochon Pharmaceutical Co., Ltd., Shanghai, CN;

Inventors:

Xingdong Zhao, Chongqing, CN;

Tongshuang Li, Surrey, CA;

Haohan Tan, Chongqing, CN;

Zhifang Chen, Chongqing, CN;

Ling Chen, Chongqing, CN;

Qihong Liu, Chongqing, CN;

Yue Rong, Chongqing, CN;

Lijun Yang, Chongqing, CN;

Xianlong Wang, Chongqing, CN;

Rui Tan, Chongqing, CN;

Zuwen Zhou, Chongqing, CN;

Bin Liu, Chongqing, CN;

Min Lin, Chongqing, CN;

Lihua Jiang, Chongqing, CN;

Yanxin Liu, Chongqing, CN;

Li Linghu, Chongqing, CN;

Jing Sun, Chongqing, CN;

Weibo Wang, Moraga, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); A61K 45/06 (2006.01); A61K 31/506 (2006.01); C07D 487/10 (2006.01); C07D 471/14 (2006.01); C07D 519/00 (2006.01); A61P 35/00 (2006.01); A61K 31/5383 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/506 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 471/14 (2013.01); C07D 487/10 (2013.01); C07D 519/00 (2013.01);
Abstract

Provided are certain CDK4/6 inhibitors with the structure of formula (I), pharmaceutical compositions thereof, and methods of use therefor. The compounds are of the class of pyrimidin-2 amine derivatives, useful for the treatment of hyper-proliferative diseases.


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