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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10450288 B1

PDFFull Text
Date of Patent:
Oct. 22, 2019

Filed:

Jan. 09, 2015

Hydroxy formamide derivatives and their use

Applicant:

Glaxosmithkline Intellectual Property (No.2) Limited, Brentford, Middlesex, GB;

Inventors:

Sarah E. Dowdell, King of Prussia, PA (US);

Hilary Schenck Eidam, King of Prussia, PA (US);

Mark Elban, King of Prussia, PA (US);

Ryan Michael Fox, Collegeville, PA (US);

Marlys Hammond, Erie, CO (US);

Mark A. Hilfiker, King of Prussia, PA (US);

Tram H. Hoang, King of Prussia, PA (US);

Lara Kallander, King of Prussia, PA (US);

Brian Griffin Lawhorn, King of Prussia, PA (US);

Sharada Manns, King of Prussia, PA (US);

Joanne Philp, King of Prussia, PA (US);

David G. Washburn, King of Prussia, PA (US);

Guosen Ye, King of Prussia, PA (US);

Assignee:

GlaxoSmithKline Intellectual Property (No. 2) Limited, Brentford, Middlesex, GB;

Attorney:

Loretta J. Sauermelch

Primary Examiner:

Rita J Desai

Int. Cl.
CPC ...
C07D 307/12 (2006.01); C07D 307/38 (2006.01); A61K 31/341 (2006.01); C07D 307/68 (2006.01); C07D 407/04 (2006.01); C07D 307/24 (2006.01); A61K 31/4025 (2006.01); A61K 31/416 (2006.01); A61K 31/428 (2006.01); A61K 31/443 (2006.01); A61K 31/665 (2006.01); C07D 405/04 (2006.01); C07D 417/04 (2006.01); C07F 9/655 (2006.01);
U.S. Cl.
CPC ...
C07D 307/68 (2013.01); A61K 31/341 (2013.01); A61K 31/4025 (2013.01); A61K 31/416 (2013.01); A61K 31/428 (2013.01); A61K 31/443 (2013.01); A61K 31/665 (2013.01); C07D 307/12 (2013.01); C07D 307/24 (2013.01); C07D 307/38 (2013.01); C07D 405/04 (2013.01); C07D 407/04 (2013.01); C07D 417/04 (2013.01); C07F 9/65515 (2013.01);
Abstract

Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.

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