The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2019
Filed:
Jan. 18, 2018
Cayman Chemical Company Incorporated, Ann Arbor, MI (US);
Kirk William Hering, Canton, MI (US);
Gilles Chambournier, Ann Arbor, MI (US);
Gregory William Endres, Saline, MI (US);
Victor Fedij, Ypsilanti, MI (US);
Thomas James Krell, II, Ypsilanti, MI (US);
Hussein Mahmoud Mahmoud, Ann Arbor, MI (US);
Cayman Chemical Company Incorporated, Ann Arbor, MI (US);
Abstract
The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein Ris a linear or branched Calkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.