The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2019
Filed:
Jun. 08, 2016
Applicant:
Xdcexplorer (Shanghai) Co., Ltd., Shanghai, CN;
Inventors:
Jason Shaoyun Xiang, Shanghai, CN;
Shifeng Liu, Shanghai, CN;
Hongyu Yang, Shanghai, CN;
Xingquan Ma, Shanghai, CN;
Assignee:
XDCEXPLORER (SHANGHAI) CO., LTD., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01); A61K 31/537 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 31/5365 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 31/5365 (2013.01); A61K 47/6855 (2017.08); A61P 35/00 (2018.01); C07D 498/18 (2013.01); C07K 16/32 (2013.01);
Abstract
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.