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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10449211 B1

PDFFull Text
Date of Patent:
Oct. 22, 2019

Filed:

Mar. 09, 2016

Compositions and methods for activating 'stimulator of interferon gene'—dependent signalling

Applicant:

Aduro Biotech, Inc., Berkeley, CA (US);

Inventors:

George Edwin Katibah, Fremont, CA (US);

David Kanne, Corte Madera, CA (US);

Leonard Sung, San Mateo, CA (US);

Kelsey Gauthier, Alameda, CA (US);

Laura Hix Glickman, Oakland, CA (US);

Justin Leong, Union City, CA (US);

Sarah M. McWhirter, Albany, CA (US);

Thomas W. Dubensky, Jr., Berkeley, CA (US);

Assignee:

ADURO BIOTECH, INC., Berkeley, CA (US);

Attorneys:

Actuity Law Group, PC

Michael A. Whittaker

Primary Examiner:

Patrick T Lewis

Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/7084 (2006.01); C07H 21/02 (2006.01); C07H 21/00 (2006.01); A61K 39/39 (2006.01); C07H 19/213 (2006.01); A61P 37/06 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 11/06 (2006.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7084 (2013.01); A61K 39/39 (2013.01); A61P 3/10 (2018.01); A61P 11/06 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 37/06 (2018.01); C07H 19/213 (2013.01); C07H 21/00 (2013.01); C07H 21/02 (2013.01); Y02A 50/463 (2018.01);
Abstract

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2'-fluoro substituted, bis-3′,5′CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs.

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