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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10449192 B1

PDFFull Text
Date of Patent:
Oct. 22, 2019

Filed:

Feb. 26, 2018

Phthalazinone derivatives

Applicant:

Kudos Pharmaceuticals Limited, Cambridge, GB;

Inventors:

Niall Morrison Barr Martin, Cambridge, GB;

Graeme Cameron Smith, Cambridge, GB;

Stephen Philip Jackson, Cambridge, GB;

Vincent Junior M Loh, Horsham, GB;

Xiao-Ling Fan Cockcroft, Horsham, GB;

Ian Timothy Williams Matthews, Horsham, GB;

Keith Allan Menear, Horsham, GB;

Frank Kerrigan, Tintagel, GB;

Alan Ashworth, London, GB;

Assignee:

KUDO PHARMACEUTICALS LIMITED, Cambridge, GB;

Attorneys:

Casimir Jones, S.C.

Mellissa E. Kolom

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 237/32 (2006.01); A61K 31/502 (2006.01); A61K 31/00 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 491/04 (2006.01); C07D 495/04 (2006.01); A61K 31/5377 (2006.01); A61K 31/551 (2006.01); A61K 45/06 (2006.01); C07D 403/14 (2006.01); A61K 31/506 (2006.01); A61N 5/10 (2006.01); C07D 243/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/502 (2013.01); A61K 31/00 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); C07D 237/32 (2013.01); C07D 243/08 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 491/04 (2013.01); C07D 495/04 (2013.01);
Abstract

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRor CRR; if X═NRthen n is 1 or 2 and if X═CRRthen n is 1; Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare both hydrogen, or when X is CRR, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; andRis selected from H and halo.

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