The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2019

Filed:

Nov. 08, 2016
Applicant:

Medical Corporation Ijunkai, Osaka, JP;

Inventor:

Hiroyuki Nakanishi, Osaka, JP;

Assignee:

Medical Corporation Ijunkai, Sakai-Shi, Osaka, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61K 47/02 (2006.01); A61K 9/14 (2006.01); A61K 9/00 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
A61K 9/501 (2013.01); A61K 9/0019 (2013.01); A61K 31/7105 (2013.01); A61K 47/02 (2013.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01);
Abstract

The present invention provides carbonate apatites with a suitable particle size (average particle size and maximum particle size) as well as small variance (σ) of particle sizes. Provided is a method of manufacturing a carbonate apatite, the method comprising the step of incubating a mixture comprising a calcium ion, a phosphate ion, and a hydrocarbon ion, wherein an incubation temperature is 10° C. or lower and an incubation time of 10 minutes or less. Further, a carbonate apatite made by this method (e.g., carbonate apatite with a maximum particle size of 700 nm, average particle size of 30 nm and drug encapsulation rate of 98%, all in nanometer size) is provided.


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