The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2019
Filed:
Oct. 19, 2016
E.r. Squibb & Sons, L.l.c., Princeton, NJ (US);
Kyowa Hakko Kirin Co. Ltd., Tokyo, JP;
Yoshimi Kuroiwa, Sioux Falls, SD (US);
Kazuma Tomizuka, Takasaki, JP;
Hitoshi Yoshida, San Diego, CA (US);
Isao Ishida, Kanagawa, JP;
E. R. Squibb & Sons, L.L.C., Princeton, NJ (US);
Kyowa Hakko Kirin Co., Ltd, Tokyo, JP;
Abstract
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.