The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
Feb. 26, 2019
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
Samie R. Jaffrey, New York, NY (US);
Jeremy Paige, La Jolla, CA (US);
Assignee:
Cornell University, Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 233/04 (2006.01); G01N 33/50 (2006.01); C12Q 1/6876 (2018.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5008 (2013.01); C07D 233/04 (2013.01); C12Q 1/6876 (2013.01); G01N 33/582 (2013.01);
Abstract
The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.