The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
Jun. 18, 2015
Calysta, Inc., Menlo Park, CA (US);
Renee M. Saville, Mountain View, CA (US);
Joshua Silverman, Los Altos Hills, CA (US);
Jeremy Minshull, Los Altos, CA (US);
Jon Edward Ness, Redwood City, CA (US);
Effendi Leonard, Anaheim, CA (US);
Jana Stumpe, Sunnyvale, CA (US);
Mark Welch, Fremont, CA (US);
CALYSTA, INC., Menlo Park, CA (US);
Abstract
The present disclosure provides nucleic acids and vectors for use with methanotrophic bacteria. Related host cells and methods for using such nucleic acids and vectors for expressing polypeptides or other genetic manipulation of methanotrophic bacteria are also provided. In one aspect, the present disclosure is directed to a non-naturally occurring nucleic acid molecule, comprising (1) a promoter that is functional in a methanotrophic bacterium, and (2) a native or altered methanol dehydrogenase (MDH) ribosomal binding sequence, provided that when the promoter is an MDH gene promoter, the nucleic acid comprises an altered MDH ribosomal binding sequence.