The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
May. 01, 2015
Applicant:
Novogy, Inc., Cambridge, MA (US);
Inventors:
Vasiliki Tsakraklides, Lexington, MA (US);
Elena E. Brevnova, Belmont, MA (US);
Assignee:
Novogy, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/79 (2006.01); C12N 15/81 (2006.01); C12N 9/10 (2006.01); C12P 7/64 (2006.01); C12N 15/80 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1029 (2013.01); C12N 15/80 (2013.01); C12P 7/6463 (2013.01); C12Y 203/0102 (2013.01); Y02E 50/13 (2013.01);
Abstract
Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up-regulating diacylglycerol acyltransferase and down-regulating triacylglycerol lipase. In some embodiments, a DGA1 protein is expressed and a native TGL3 gene is knocked out, thereby increasing the synthesis of triacylglycerol and decreasing its consumption, respectively.