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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10442838 B1

PDFFull Text
Date of Patent:
Oct. 15, 2019

Filed:

Dec. 15, 2016

Linaclotide synthesis method

Applicant:

Hybio Pharmaceutical Co., Ltd., Shenzhen, Guangdong, CN;

Inventors:

Xueming Chen, Guangdong, CN;

Jingkang Wu, Guangdong, CN;

Pengcheng Mi, Guangdong, CN;

Anjin Tao, Guangdong, CN;

Jiancheng Yuan, Guangdong, CN;

Assignee:

HYBIO PHARMACEUTICAL CO., LTD., Shenzhen, Guangdong, CN;

Attorneys:

Yue (Robert) Xu

Apex Attorneys at Law, LLP

Primary Examiner:

Satyanarayana R Gudibande

Int. Cl.
CPC ...
A61K 38/12 (2006.01); C07K 7/64 (2006.01); C07K 1/04 (2006.01); C07K 1/06 (2006.01); C07K 1/20 (2006.01); C07K 7/08 (2006.01); C07K 1/16 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); C07K 1/04 (2013.01); C07K 1/042 (2013.01); C07K 1/06 (2013.01); C07K 1/16 (2013.01); C07K 1/20 (2013.01); C07K 7/08 (2013.01); C12P 21/02 (2013.01); C12Y 111/01007 (2013.01); Y02P 20/55 (2015.11);
Abstract

Disclosed is a method of synthesizing linaclotide through completely selective formation of three disulfide bonds, comprising the steps of: 1) synthesizing linaclotide precursor resin through solid-phase synthesis; 2) forming the first disulfide bond through solid phase oxidation; 3) forming the second disulfide bond through liquid phase oxidation; and 4) deprotecting methyl in the methyl-protected cysteine, and oxidatively coupling the third disulfide bond to obtain linaclotide. The method has mild reaction conditions with low cost, high yield and high purity product, is a simple and stable process and is suitable for large-scale production.

Find Patent Forward Citations

Chen, Xueming. (2019). Linaclotide synthesis method (U.S. Patent No. 10442838). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10442838

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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