The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
Jun. 16, 2014
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
John Flygare, Burlingame, CA (US);
Thomas Pillow, San Francisco, CA (US);
Brian Safina, Belmont, CA (US);
Vishal Verma, San Carlos, CA (US);
Binqing Wei, Belmont, CA (US);
William Denny, Auckland, NZ;
Anna Giddens, Auckland, NZ;
Ho Lee, Auckland, NZ;
Guo-Liang Lu, Auckland, NZ;
Christian Miller, Auckland, NZ;
Gordon Rewcastle, Auckland, NZ;
Moana Tercel, Auckland, NZ;
Muriel Bonnet, Auckland, NZ;
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/28 (2006.01); C07D 207/40 (2006.01); C07D 209/60 (2006.01); C07K 5/062 (2006.01); C07D 487/04 (2006.01); C07D 209/62 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07F 9/6558 (2006.01); C07H 15/24 (2006.01); C07K 16/32 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07K 16/00 (2006.01); C07K 16/30 (2006.01); A61K 47/55 (2017.01); C07F 9/572 (2006.01); C07F 9/6561 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06052 (2013.01); A61K 47/55 (2017.08); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); C07D 207/40 (2013.01); C07D 209/60 (2013.01); C07D 209/62 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07F 9/572 (2013.01); C07F 9/6561 (2013.01); C07F 9/65583 (2013.01); C07H 15/24 (2013.01); C07K 16/00 (2013.01); C07K 16/2803 (2013.01); C07K 16/3061 (2013.01); C07K 16/3069 (2013.01); C07K 16/32 (2013.01);
Abstract
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.