The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 15, 2019

Filed:

Nov. 09, 2016
Applicant:

Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, CN;

Inventors:

Haibo Wang, Taizhou, CN;

Hongfu Kuang, Taizhou, CN;

Wei Zhang, Taizhou, CN;

Zhengjiang Cai, Taizhou, CN;

Tianmin Zhu, Taizhou, CN;

Xiaohe Zheng, Taizhou, CN;

Zhongwei Wu, Taizhou, CN;

Zhiqing Yang, Taizhou, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 5/02 (2006.01); A61P 35/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 5/0215 (2013.01); A61P 35/00 (2018.01); A61K 38/00 (2013.01);
Abstract

The present invention relates to technical fields of organic chemistry and pharmaceutical chemistry, specifically to water-soluble rapamycin derivatives modified with glutathione. More specifically, the present invention discloses a compound of formula I and the preparation method thereof, wherein Rand Rare as defined in the description. The compound of formula I can be used in inducing immunosuppression and in the treatment of diseases such as transplant rejection and solid tumor, etc.


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