The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
Jun. 28, 2018
Applicant:
Topivert Pharma Limited, London, GB;
Inventors:
Matthew Colin Thor Fyfe, London, GB;
Stephen Malcolm Thom, Nottingham, GB;
Assignee:
Topivert Pharma Limited, London, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/443 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/501 (2006.01); A61K 31/505 (2006.01); A61K 31/675 (2006.01); C07D 213/73 (2006.01); C07D 239/47 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 403/12 (2006.01); A61K 31/506 (2006.01); C07D 213/74 (2006.01); A61K 45/06 (2006.01); A61K 31/4412 (2006.01); C07F 9/58 (2006.01);
U.S. Cl.
CPC ...
C07F 9/58 (2013.01); A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/4412 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/501 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 213/73 (2013.01); C07D 213/74 (2013.01); C07D 239/47 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01);
Abstract
There are provided compounds of: wherein T, A, Q, Z, R, R, R, n, r, Hetand Rhave meanings given in the description, which compounds are useful in synthesizing compounds that have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.