The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 15, 2019

Filed:

Dec. 01, 2015
Applicants:

Christian Fischer, Natick, MA (US);

Stephane L. Bogen, Somerset, NJ (US);

Matthew L. Childers, Medfield, MA (US);

Francesc Xavier Fradera Llinas, Brookline, MA (US);

J. Michael Ellis, Needham, MA (US);

Sara Esposite, Houston, PA (US);

Qingmei Hong, Scotch Plains, NJ (US);

Chunhui Huang, Arlington, MA (US);

Alexander J. Kim, Eastvale, CA (US);

John W. Lampe, Norfolk, MA (US);

Michelle R. Machacek, Belmont, MA (US);

Daniel R. Mcmasters, Brookline, MA (US);

Ryan D. Otte, Natick, MA (US);

Dann L. Parker, Jr., Cranford, NJ (US);

Michael Reutershan, Brighton, MA (US);

Nunzio Sciammetta, Sudbury, MA (US);

Pengcheng P. Shao, Fanwood, NJ (US);

David L. Sloman, Brookline, MA (US);

Feroze Ujjainwalla, Ridgewood, NJ (US);

Catherine White, Newton Center, MA (US);

Zhicai Wu, Montvale, NJ (US);

Yang Yu, Edison, NJ (US);

Kake Zhao, Westfield, NJ (US);

Craig Gibeau, Holliston, MA (US);

Tesfaye Biftu, Freehold, NJ (US);

Purakkattle Biju, Westwood, MA (US);

Lei Chen, Basking Ridge, NJ (US);

Joshua Close, Franklin, MA (US);

Peter H. Fuller, Ashland, MA (US);

Xianhai Huang, Warren, NJ (US);

Min K. Park, Morristown, NJ (US);

Valdimir Simov, Boston, MA (US);

David J. Witter, Norfolk, MA (US);

Hongjun Zhang, Boston, MA (US);

Inventors:

Christian Fischer, Natick, MA (US);

Stephane L. Bogen, Somerset, NJ (US);

Matthew L. Childers, Medfield, MA (US);

Francesc Xavier Fradera Llinas, Brookline, MA (US);

J. Michael Ellis, Needham, MA (US);

Sara Esposite, Houston, PA (US);

Qingmei Hong, Scotch Plains, NJ (US);

Chunhui Huang, Arlington, MA (US);

Alexander J. Kim, Eastvale, CA (US);

John W. Lampe, Norfolk, MA (US);

Michelle R. Machacek, Belmont, MA (US);

Daniel R. McMasters, Brookline, MA (US);

Ryan D. Otte, Natick, MA (US);

Dann L. Parker, Jr., Cranford, NJ (US);

Michael Reutershan, Brighton, MA (US);

Nunzio Sciammetta, Sudbury, MA (US);

Pengcheng P. Shao, Fanwood, NJ (US);

David L. Sloman, Brookline, MA (US);

Feroze Ujjainwalla, Ridgewood, NJ (US);

Catherine White, Newton Center, MA (US);

Zhicai Wu, Montvale, NJ (US);

Yang Yu, Edison, NJ (US);

Kake Zhao, Westfield, NJ (US);

Craig Gibeau, Holliston, MA (US);

Tesfaye Biftu, Freehold, NJ (US);

Purakkattle Biju, Westwood, MA (US);

Lei Chen, Basking Ridge, NJ (US);

Joshua Close, Franklin, MA (US);

Peter H. Fuller, Ashland, MA (US);

Xianhai Huang, Warren, NJ (US);

Min K. Park, Morristown, NJ (US);

Valdimir Simov, Boston, MA (US);

David J. Witter, Norfolk, MA (US);

Hongjun Zhang, Boston, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/351 (2006.01); A61K 31/4353 (2006.01); A61K 31/5355 (2006.01); A61K 31/551 (2006.01); C07D 471/04 (2006.01); C07D 471/14 (2006.01); C07D 498/08 (2006.01); C07D 471/08 (2006.01); C07D 498/04 (2006.01); C07D 498/10 (2006.01); A01N 43/00 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); A61K 31/551 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 471/14 (2013.01); C07D 498/04 (2013.01); C07D 498/10 (2013.01); A01N 43/00 (2013.01);
Abstract

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.


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