The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
Dec. 06, 2017
Applicant:
Sutro Biopharma, Inc., South San Francisco, CA (US);
Inventors:
Wenjin Yang, Foster City, CA (US);
Qun Yin, Palo Alto, CA (US);
Assignee:
SUTRO BIOPHARMA, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 257/08 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01); C07K 5/078 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); C12N 9/00 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61K 47/6803 (2017.08); A61K 47/6811 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6855 (2017.08); A61K 47/6871 (2017.08); C07D 257/08 (2013.01); C07D 409/12 (2013.01); C07K 5/06139 (2013.01); C07K 16/22 (2013.01); C07K 16/28 (2013.01); C07K 16/2833 (2013.01); C07K 16/2878 (2013.01); C07K 16/40 (2013.01); C12N 9/93 (2013.01); C12P 21/00 (2013.01); C12P 21/02 (2013.01); C07K 2317/24 (2013.01); C07K 2317/40 (2013.01); C07K 2317/50 (2013.01); C07K 2317/526 (2013.01); C07K 2317/567 (2013.01); C07K 2317/76 (2013.01); C12Y 601/01001 (2013.01);
Abstract
Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and methods of producing the polypeptides, antibodies, payloads and conjugates comprising the modified amino acid residues. The polypeptides, antibodies, payloads and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.