The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 15, 2019

Filed:

Mar. 17, 2017
Applicant:

Merck Sharp & Dohme Corp., Kenilworth, NJ (US);

Inventors:

Anthony J. Roecker, Harleysville, PA (US);

Mark E. Layton, Harleysville, PA (US);

Thomas J. Greshock, Collegeville, PA (US);

Joseph E. Pero, Harleysville, PA (US);

Michael J. Kelly, III, Paoli, PA (US);

Ting Zhang, Princeton Junction, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 277/52 (2006.01); C07D 285/08 (2006.01); A61K 31/635 (2006.01); A61K 45/06 (2006.01); A61K 31/18 (2006.01); A61K 31/427 (2006.01); A61K 31/426 (2006.01); A61K 31/433 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07D 277/52 (2013.01); A61K 31/18 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/433 (2013.01); A61K 31/635 (2013.01); A61K 45/06 (2013.01); C07D 285/08 (2013.01); C07F 7/0812 (2013.01);
Abstract

Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.


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