The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 15, 2019

Filed:

Mar. 19, 2015
Applicants:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

University of Leeds, Leeds, GB;

Inventors:

Jose S. Pulido, Rochester, MN (US);

Richard G. Vile, Rochester, MN (US);

Timothy J. Kottke, Oronoco, MN (US);

Jill M. Thompson, Stewartville, MN (US);

Rosa Maria Diaz, Rochester, MN (US);

Christine Marie Pulido, Rochester, MN (US);

Alan A. Melcher, Leeds, GB;

Peter Selby, Leeds, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 35/766 (2015.01); C07K 14/82 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0011 (2013.01); A61K 35/766 (2013.01); A61K 39/00 (2013.01); C07K 14/82 (2013.01); C07K 16/28 (2013.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2039/53 (2013.01); A61K 2039/70 (2013.01); C12N 2760/20243 (2013.01);
Abstract

This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.


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