The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 08, 2019

Filed:

Jun. 07, 2017
Applicant:

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Charles M. Lieber, Lexington, MA (US);

Ping Xie, Needham, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/327 (2006.01); G01N 27/447 (2006.01); B82Y 30/00 (2011.01); C12Q 1/6869 (2018.01); G01N 33/487 (2006.01); B82Y 15/00 (2011.01);
U.S. Cl.
CPC ...
G01N 27/447 (2013.01); B82Y 30/00 (2013.01); C12Q 1/6869 (2013.01); G01N 33/48721 (2013.01); B82Y 15/00 (2013.01);
Abstract

There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.


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