The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 08, 2019

Filed:

Mar. 09, 2015
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Marek Honczarenko, Princeton, NJ (US);

Vaishali Shah, Pennington, NJ (US);

Xiaoni Liu, Princeton, NJ (US);

Wendy L. Trigona, Princeton, NJ (US);

Rong Shi, Princeton, NJ (US);

Suzanne J. Suchard, Wilmington, DE (US);

Karen D. Price, New Brunswick, NJ (US);

Linda M. Gustavson, Princeton, NJ (US);

Assignee:

BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 47/60 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 47/60 (2017.08); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/35 (2013.01); C07K 2317/52 (2013.01); C07K 2317/53 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01);
Abstract

A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single Vor Vdomain and an Fc domain.


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