The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2019
Filed:
Aug. 06, 2015
Albert Einstein College of Medicine, Inc., Bronx, NY (US);
The Governing Councel of the University of Toronto, Toronto, CA;
U.s. Army Medical Research and Material Command, Fort Detrick, MD (US);
Jonathan R. Lai, Dobbs Ferry, NY (US);
Jayne F. Koellhoffer, New York, NY (US);
Julia Frei, Bronx, NY (US);
Kartik Chandran, Brooklyn, NY (US);
Sachdev Sidhu, Toronto, CA;
Gang Chen, Toronto, CA;
John M. Dye, Frederick, MD (US);
Samantha Zak, Frederick, MD (US);
Albert Einstein College of Medicine, Bronx, NY (US);
The Governing Council of the University of Toronto, Toronto, CA;
The Government of the United States as Represented by the Secretary of the Army, Fort Detrick, MD (US);
Abstract
The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.