The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2019
Filed:
Jul. 31, 2015
Applicant:
Genesen Co., Ltd., Seoul, KR;
Inventors:
Assignee:
Genesen Co., Ltd., Seoul, KR;
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/00 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 16/28 (2006.01); A61K 38/04 (2006.01); A61K 38/10 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4703 (2013.01); A61P 29/00 (2018.01); A61P 37/00 (2018.01); C07K 7/08 (2013.01); C07K 14/47 (2013.01); A61K 38/00 (2013.01); C07K 16/2896 (2013.01);
Abstract
Provided is a peptide that binds to a toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) composite and inhibit secretion of interleukin-6 (IL-6), nitrogen monoxide (NO) and reactive oxygen species (ROS), and activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and mitogen-activated protein kinases (MAPKs) via inhibiting a TLR4 signaling pathway induced by a liphopolysaccharide (LPS); a TLR4 antagonist including the peptide; and a composition thereof for preventing or treating autoimmune diseases and inflammatory diseases.