The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 08, 2019

Filed:

Nov. 06, 2017
Applicant:

Korea Institute of Science and Technology, Seoul, KR;

Inventors:

Hyunah Choo, Seoul, KR;

Youngjae Kim, Seoul, KR;

Jihye Seong, Seoul, KR;

Ghil Soo Nam, Seoul, KR;

Yong Seo Cho, Seoul, KR;

Attorney:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 498/04 (2006.01); A61K 31/55 (2006.01); A61K 31/4162 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4162 (2013.01); A61K 31/55 (2013.01); A61P 25/22 (2018.01); A61P 25/24 (2018.01); C07D 498/04 (2013.01); Y02P 20/55 (2015.11);
Abstract

Azepine derivatives acting on 5-HTreceptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HTreceptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HTreceptors antagonistic activity is required.


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