The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2019
Filed:
Jan. 30, 2017
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Cheol K. Chung, Westfield, NJ (US);
Mark E. Scott, Alberta, CA;
Paul Gerard Bulger, Jersey City, NJ (US);
Kevin Michael Belyk, Metuchen, NJ (US);
John Limanto, Jersey City, NJ (US);
Guy R. Humphrey, Hillsborough, NJ (US);
MERCK SHARP & DOHME CORP., Rahway, NJ (US);
Abstract
A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.