The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2019
Filed:
Nov. 21, 2018
Applicant:
Magenta Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Adam Hartigan, Brookline, MA (US);
Anthony Boitano, Newton, MA (US);
Michael Cooke, Brookline, MA (US);
Megan D. Hoban, Medford, MA (US);
Rahul Palchaudhuri, Somerville, MA (US);
Assignee:
Magenta Therapeutics, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/28 (2006.01); A61P 37/06 (2006.01); A61K 38/08 (2019.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6831 (2017.08); A61K 38/08 (2013.01); A61K 39/395 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61P 37/06 (2018.01); C07K 16/2878 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); A61K 2039/572 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind CD137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions.