The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2019
Filed:
Nov. 17, 2015
Centro DE Ingeniería Genetica Y Biotecnología, Havana, CU;
Celia Berta Fernandez Ortega, Havana, CU;
Anna Caridys Ramírez Suarez, Havana, CU;
Dionne Casillas Casanova, Havana, CU;
Taimi Emelia Paneque Guerrero, Havana, CU;
Raimundo Ubieta Gomez, Havana, CU;
Marta Dubed Echevarria, Havana, CU;
Leonor Margarita Navea Leyva, Havana, CU;
Lila Rosa Castellanos Serra, Havana, CU;
Carlos Antonio Duarte Cano, Havana, CU;
Viviana Falcon Cama, Havana, CU;
Osvaldo Reyes Acosta, Havana, CU;
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA, Havana, CU;
Abstract
The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the the proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, including peptides and/or interfering RNA and/or lipidic compounds, the agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection.