The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2019
Filed:
Jul. 27, 2016
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Rafael Guerrero-Preston, Baltimore, MD (US);
David Sidransky, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6886 (2018.01); A61B 34/10 (2016.01); A61B 1/303 (2006.01); A61B 5/00 (2006.01); A61N 5/10 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61B 1/303 (2013.01); A61B 5/0084 (2013.01); A61B 34/10 (2016.02); A61N 5/1039 (2013.01); C12N 15/1093 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/154 (2013.01);
Abstract
Methods and kits for triaging a human papillomavirus (HPV)-positive woman into colposcopy are disclosed. The methods comprise determining the promoter methylation level of the promoter regions of a group of genes (e.g., viral and host genes) that exhibit increased promoter methylation in women having CIN2+ lesions as compared to women having no intraepithelial lesions or malignancy (NILM).