The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 01, 2019

Filed:

Jul. 19, 2017
Applicant:

Omniome, Inc., San Diego, CA (US);

Inventors:

Pinar Iyidogan, San Diego, CA (US);

Kandaswamy Vijayan, San Diego, CA (US);

Assignee:

OMNIOME, INC., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12Q 1/686 (2018.01); C12Q 1/6806 (2018.01); C12Q 1/6813 (2018.01); C12Q 1/6853 (2018.01); G01N 27/447 (2006.01); C12Q 1/6869 (2018.01); G01N 21/45 (2006.01); C12Q 1/00 (2006.01); G01N 1/40 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/686 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6813 (2013.01); C12Q 1/6853 (2013.01); C12Q 1/6869 (2013.01); G01N 21/45 (2013.01); G01N 27/447 (2013.01); C12Q 1/00 (2013.01); G01N 2001/4038 (2013.01);
Abstract

Provided are methods and systems for reducing the time needed for sequencing nucleic acids. The approach relies on detecting formation of nucleotide-specific ternary complexes comprising a polymerase (e.g., a DNA polymerizing enzyme), a primed template nucleic acid molecule, and a nucleotide complementary to the templated base of the primed template nucleic acid. The methods and systems facilitate determination of the next correct nucleotide, as well as the subsequent next correct nucleotide from a cycle of examining four different nucleotides without requiring chemical incorporation of any nucleotide into the primer.


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