The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2019
Filed:
Sep. 06, 2016
Eisai R&d Management Co., Ltd., Tokyo, JP;
Ryota Taguchi, Kobe, JP;
Toshio Imai, Kobe, JP;
Eiji Inoue, Kobe, JP;
Akio Yamada, Kobe, JP;
Aki Nakatani, Kobe, JP;
Toshifumi Hirayama, Kobe, JP;
Yuichi Ono, Kobe, JP;
Shunsuke Ito, Kobe, JP;
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
It is intended to provide an anti-EphA4 antibody or an EphA4-binding fragment thereof which is capable of binding to EphA4 and inhibiting the binding between EphA4 and its ligand, and a pharmaceutical composition comprising the anti-EphA4 antibody or the EphA4-binding fragment thereof as an active ingredient. A mouse anti-EphA4 antibody having binding affinity for EphA4 was obtained, and the sequences of complementarity-determining regions (CDRs) of the mouse anti-EphA4 antibody were identified. This allowed for preparation of a humanized antibody comprising the CDR sequences of the mouse anti-EphA4 antibody in heavy chain variable region and light chain variable region.