The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2019
Filed:
Jun. 27, 2018
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Raphaelle Berger, New York, NY (US);
Yi-Heng Chen, Whippany, NJ (US);
Guoqing Li, Belle Mead, NJ (US);
Joie Garfunkle, Kriens, CH;
Hong-Dong Li, Edison, NJ (US);
Shouwu Miao, Edison, NJ (US);
Subharekha Raghavan, Teaneck, NJ (US);
Cameron J. Smith, Montgomery Village, MD (US);
John Stelmach, Westfield, NJ (US);
Alan Whitehead, Scotch Plains, NJ (US);
Rui Zhang, Plainsboro, NJ (US);
Yong Zhang, West Windsor, NJ (US);
Jianmin Fu, Beijing, CN;
Gang Ji, Beijing, CN;
Falong Jiang, Beijing, CN;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R, R, R, R, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ('cGMP'), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.