The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2019
Filed:
Nov. 16, 2012
The Johns Hopkins University, Baltimore, MD (US);
Michael S. Yu, Timonium, MD (US);
Yang Li, Baltimore, MD (US);
Daniel Summerfield, Baltimore, MD (US);
Allen Yi-Lan Wang, Belle Mead, NJ (US);
Catherine A. Foss, Baltimore, MD (US);
Martin G. Pomper, Baltimore, MD (US);
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Abstract
The present invention provides both a caged collagen mimetic peptide (CCMP) having the formula: L-S-Z-[Gly-X-Y]-Gly-X-Y-[Gly-X-Y](SEQ ID NO:); wherein L is one or more detectable moieties; S is one or more spacer molecules; Zis any amino acid where m is an integer of 1 to 10; X is proline or modified proline; Y is proline or modified proline; Gly is glycine; n is an integer from 1 to 20; andGly is a glycine covalently linked to a cage moiety comprising a labile protecting group, as well as a collagen mimetic peptides lacking the labile protecting group (CMP). The inventions are useful for binding collagen and denatured collagen and/or gelatin both in vitro and in vivo, and are useful for targeting any organ or tissue where collagen is present, and can be used for research and diagnostic imaging (both in vivo and in vitro) and also for in vivo therapeutic applications.