The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2019
Filed:
Apr. 22, 2016
International Vaccine Institute, Seoul, KR;
International Vaccine Institute, Seoul, KR;
Abstract
The present invention relates to astrain, of which the surface exposure of a protective antigen existing on a cellular membrane is increased due to the destruction of a wzy gene ofsp., and to a vaccine composition for treating or preventing shigellosis, containing the mutantstrain as an active ingredient. Thestrain of the present invention has a cell wall with a reduced thickness since a gene encoding a protein necessary for polymerization of the O-saccharide antigen is deleted, and as a result, membrane antigens including protein antigens commonly existing in differentspp. are more exposed to immune cells, and thus thestrain can be favorably used as a vaccine composition for treating or preventing shigellosis, derived from variousspp.