The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 01, 2019

Filed:

Apr. 01, 2009
Applicants:

Harsh M. Trivedi, Somerset, NJ (US);

Tao Xu, Newton, MA (US);

Davide Miksa, Doylestown, PA (US);

Cortney Worrell, Salem, CT (US);

Chanda Macias, Somerset, NJ (US);

Ying Yang, Monmouth Junction, NJ (US);

Yanan HU, San Jose, CA (US);

Inventors:

Harsh M. Trivedi, Somerset, NJ (US);

Tao Xu, Newton, MA (US);

Davide Miksa, Doylestown, PA (US);

Cortney Worrell, Salem, CT (US);

Chanda Macias, Somerset, NJ (US);

Ying Yang, Monmouth Junction, NJ (US);

Yanan Hu, San Jose, CA (US);

Assignee:

Colgate-Palmolive Company, New York, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/33 (2006.01); A61K 31/265 (2006.01); A61K 8/37 (2006.01); A61K 8/41 (2006.01); A61K 8/42 (2006.01); A61K 31/27 (2006.01); A61Q 11/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/265 (2013.01); A61K 8/375 (2013.01); A61K 8/411 (2013.01); A61K 8/42 (2013.01); A61K 31/27 (2013.01); A61Q 11/00 (2013.01);
Abstract

The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.


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