The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2019
Filed:
Jun. 07, 2018
Applicant:
Modernatx, Inc., Cambridge, MA (US);
Inventors:
Paolo Martini, Boston, MA (US);
Vladimir Presnyak, Cambridge, MA (US);
Assignee:
ModernaTX, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 9/51 (2006.01); A61K 9/127 (2006.01); C12N 9/90 (2006.01); A61P 3/00 (2006.01); A61P 43/00 (2006.01); A61K 38/52 (2006.01); A61K 48/00 (2006.01); C12N 15/52 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5123 (2013.01); A61K 9/1272 (2013.01); A61K 38/52 (2013.01); A61K 48/005 (2013.01); A61P 3/00 (2018.01); A61P 43/00 (2018.01); C12N 9/90 (2013.01); C12N 15/52 (2013.01); C12Y 504/99002 (2013.01); A61K 38/00 (2013.01);
Abstract
The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.