The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Mar. 02, 2017
Flagship Biosciences, Inc., Westminster, CO (US);
Joseph Krueger, Westminster, CO (US);
Nathan T. Martin, Westminster, CO (US);
Flagship Biosciences, Inc., Westminster, CO (US);
Abstract
Staining of tissue is a common approach utilized to visualize a gene product in tissue context. In certain applications, it is necessary to report a sum of events within the tissue as a specific function of the target tissue area, which is a sub-area of the total tissue, as a normalization factor for reporting the quantification. Here, we describe methods of determining target tissue area and reporting a quantification which is ratiometric to the target tissue area, utilizing computer algorithms. It is important to assign a value for the 'target tissue area' in scenarios where a tissue area normalization factor is needed in the most pathologically relevant fashion during the application of tissue image analysis. We have created methods for determining and reporting 'target tissue area' as normalization factor which are useful in diagnostic applications utilizing image analysis.