The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Feb. 11, 2016
Applicant:
Alma Mater Studiorum Universita'di Bologna, Bologna, IT;
Inventors:
Maria Gabriella Campadelli, Bologna, IT;
Valentina Gatta, Bologna, IT;
Assignee:
Alma Mater Studiorum Universita' Di Bologna, Bologna, IT;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/869 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); C12N 15/62 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/869 (2013.01); C12N 5/10 (2013.01); C12N 7/00 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); A61K 39/00 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/5256 (2013.01); C12N 2710/16032 (2013.01); C12N 2710/16632 (2013.01);
Abstract
The present invention relates to the field of disease therapy. More specifically, it relates to a retargeted herpesvirus having a heterologous polypeptide fused to glycoprotein H, wherein the polypeptide targets diseased cells. It also relates to a nucleic acid comprising the genome of the herpesvirus of the invention, a vector comprising this nucleic acid and a cell comprising the nucleic acid or the vector. It further relates to killing cells using the herpesvirus of the invention and to methods for growing it in vitro.