The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2019

Filed:

Aug. 24, 2015
Applicant:

The Usa, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);

Inventors:

Bernard Moss, Bethesda, MD (US);

Linda S. Wyatt, Rockville, MD (US);

Patricia L. Earl, Chevy Chase, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/863 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C12N 15/8636 (2013.01); A61K 2039/5256 (2013.01); C12N 2710/24111 (2013.01); C12N 2710/24141 (2013.01); C12N 2710/24143 (2013.01); C12N 2710/24152 (2013.01);
Abstract

The present invention relates to new insertion sites useful for the integration of exogenous sequences into an intergenic region (IGR) of a vaccinia virus genome, where the IGR is located between or is flanked by two adjacent open reading frames (ORFs) of the vaccinia virus genome, and where the ORFs correspond to conserved genes, and to related plasmid vectors useful to insert exogenous DNA into the genome of a vaccinia virus, and further to recombinant vaccinia viruses comprising an exogenous sequence inserted into said new insertion site as a medicine or vaccine.


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