The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Mar. 15, 2017
Versitech Limited, Hong Kong, CN;
Centre National DE LA Recherche Scientifique, Paris, FR;
Université D'aix-marseille, Marseilles, FR;
The Chinese University of Hong Kong, Hong Kong, CN;
Alice S. T. Wong, Hong Kong, CN;
Jing Ma, Hong Kong, CN;
Ling Peng, Paris, FR;
K. W. Lo, Hong Kong, CN;
Versitech Limited, Hong Kong, CN;
Centre National de la Recherche Scientifique, Paris, FR;
Université´ d'Aix-Marseille, Paris, FR;
The Chinese University of Hong Kong, Hong Kong, CN;
Abstract
The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit enhanced siRNA delivery. The amphiphilic dendriplexes containing Bcl3 siRNA inhibit cancer cell/tumor growth in vitro and in vivo without toxicity. Accordingly, an embodiment of the invention provides a method of treating a cancer, particularly, nasopharyngeal carcinoma, by administering to a subject in need thereof, a therapeutic amount of amphiphilic dendrimers complexed with Bcl3 siRNA. Pharmaceutical compositions containing the amphiphilic dendrimers complexed with Bcl3 siRNA are also provided.