The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2019

Filed:

May. 26, 2016
Applicant:

Ucb Pharma S.a., Brussels, BE;

Inventors:

Ralph Adams, Slough, GB;

Emma Dave, Slough, GB;

David Paul Humphreys, Slough, GB;

Assignee:

UCB BIOPHARMA SPRL, Brussels, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 16/28 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 16/18 (2013.01); C07K 16/2875 (2013.01); C07K 16/468 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/522 (2013.01); C07K 2317/53 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/624 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.


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